Just like The Karate Kid 2, it seems that The Incredibles 2 picks up right where the first one left off. That's great new, sequel-wise, so you don't have to spend the first act catching up on what transpired since the previous film.
There's a lot to look forward to with Mr. Incredible/Bob Parr taking on the title of Mr. Mom and a lot of action from Jack Jack. Personally, I cannot wait for June 15th!